Serial Killing of Tumor Cells by Human Natural Killer Cells – Enhancement by Therapeutic Antibodies
نویسندگان
چکیده
منابع مشابه
Serial Killing of Tumor Cells by Human Natural Killer Cells – Enhancement by Therapeutic Antibodies
BACKGROUND Natural killer cells are an important component of the innate immune system. Anti-cancer therapies utilizing monoclonal antibodies also rely on the cytotoxicity of NK cells for their effectiveness. Here, we study the dynamics of NK cell cytotoxicity. METHODOLOGY/PRINCIPAL FINDINGS We observe that IL-2 activated human NK cells can serially hit multiple targets. Using functional assa...
متن کاملPotassium channels mediate killing by human natural killer cells.
Human natural killer (NK) cells in peripheral blood spontaneously recognize and kill a wide variety of target cells. It has been suggested that ion channels are involved in the killing process because there is a Ca-dependent stage and because killings by presensitized cytotoxic T lymphocytes, which in many respects resembles NK killing, is associated with changes in K and Na transport in the ta...
متن کاملEnhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications.
Natural killer T (NKT) cells are CD1d-restricted glycolipid reactive innate lymphocytes that play an important role in protection from pathogens and tumors. Pharmacologic approaches to enhance NKT cell function will facilitate specific NKT targeting in the clinic. Here we show that lenalidomide (LEN), a novel thalidomide (Thal) analog, enhances antigen-specific expansion of NKT cells in respons...
متن کاملNatural killing of tumor cells by human peripheral blood cells. Suppression of killing in vitro by tumor-promoting phorbol diesters.
Tumor-promoting phorbol diesters were shown to suppress natural killing in vitro by human peripheral blood mononuclear cells. The inhibitory effect of different phorbol diesters and their analogues correlated with their potency as tumor promoters, the most effective agent being 12-O-tetradecanoylphorbol-13-acetate (TPA). Both peripheral blood cells and targets specifically bound TPA, and natura...
متن کاملcytotoxicity of human cord blood natural killer cells is enhanced by recombinant interleukin-15
hematopoietic cord blood (cb) stem cell transplantation has more advantages to other cell sources because of lower graft versus host disease (gvhd). interleukin-15(il-15) is an immunoregulatory cytokine, known to enhance cytolytic function of cord natural killer (nk) cells. the aim of this study was to investigate the effect of il-15 on nk cytotoxicity simultaneously in different cell death sta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2007
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0000326